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Dalbavancin: A novel long-acting lipoglycopeptide antibiotic

Dalbavancin is a new lipoglycopeptide antibiotic in phase 3 trials for the treatment of resistant gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). This agent exerts its bactericidal activity by binding to the terminal D-alanyl-D-alanine moiety of peptidoglycan precursors, thus blocking enzymes involved in the final stages of peptidoglycan synthesis and cell wall formation. Peak concentrations of dalbavancin occur immediately following infusion and increase in proportion to the dose given.
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Drug Benefit Experts Invest in Pharmacy Benefit Management Institute

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Pre-approval Feature

Focus On: Exubera An Orally inhaled insulin

Long-term glycemic control substantially reduces the risk of diabetes mellitus-related complications. Insulin is a mainstay in therapy in type 1 and later-stage type 2 diabetes mellitus. Although insulin is effective in controlling blood glucose and hemoglobin A1c concentrations, the need for subcutaneous injection can be a burden for patients, which can impact compliance. Exubera (Nektar Therapeutics/Pfizer/Sanofi-Aventis) is an inhaled insulin that has demonstrated results similar to conventional short-acting insulin products while also increasing overall patient satisfaction.
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Herb-drug interactions

Interactions between ginseng and prescription medications

Ginseng has been recommended for a wide variety of uses including amelioration of physical and mental performance, but there is little evidence of its efficacy. Evidence shows that it has some value in infection resistance, reducing stress, lowering cholesterol and blood sugar levels, and has a modest estrogen-like effect on women.
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Endocrinology

Pharmacologic options for the management of diabetic peripheral neuropathy

Diabetic peripheral neuropathy, one of the most common late complications of diabetes, is associated with decreased quality of life and increased morbidity. The pathophysiology of diabetic neuropathy (DN) is multifactorial, contributing to ischemic and painful events and neuronal damage.
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Drugs and Race: Targeting medication to racial groups—what the future holds and why it's controversial

The Food & Drug Administration's recent approval of isosorbide dinitrate/hydralazine in African-Americans left some clinicians and civil rights groups scratching their heads. Was it a good or bad thing to target a drug to a specific race?
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Industry Roundup

Drug-eluting stents best used in select patients

 


New antifungal offers another option

 


Imatinib-like agents on way to treat CML

 


FDA eases passage for constipation drug

 
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